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Adrival administration of aspirin before surgery does not increase the risk of intraoperative bleeding


A study in Australia showed that aspirin administration of CABG did not increase intraoperative bleeding. (NEnglJ Med. 2016, 374: 728)

There is a significant difference in how the cardiopulmonary surgeon manages CABG preoperative use of aspirin. More than half of the doctors recommend patients to disable aspirin 5-7 days before surgery, other doctors believe that the continued use of aspirin can prevent myocardial infarction or stroke.

The study included 1047 patients receiving enteric-coated aspirin 100 mg and 1053 placebo, both within 1-2 h before surgery.

The results showed that there was no significant difference in the risk of thrombosis, thrombosis or hemorrhage between the two groups. The incidence of death and / or thrombotic complications in aspirin and placebo group was 19.3% and 20.4% in 30 days, 1.8% and 2.1% of patients with bleeding due to re-operation, each with 1.1% and 0.4% of cardiac tamponade, no significant difference.

The researchers believe that the safety of aspirin may be related to the dose, the previous aspirin dose than the study with 2-5 times higher.

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