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Use of oral contraceptives overweight or obese women to be alert to cerebral venous thrombosis


A multinational study shows that obesity is a strong risk factor for cerebral venous thrombosis (CVT) in women who use oral contraceptives. The paper was published in the March 14 issue of JAMA Neurol.

A total of 186 patients with CVT and 6134 controls were enrolled.

The results showed that compared with the control group, CVT group, the patients are younger, more women, female patients more often use oral contraceptives, and associated with a higher proportion of cancer history. Obesity [body mass index (BMI) ≥30] is associated with an increased risk of CVT. According to gender stratification, CVT was only strongly associated with obesity in women. Further stratification revealed that overweight and obesity were associated with increased risk of CVT in a dose-dependent manner in women who used oral contraceptives. The above correlations were not observed in women who did not use oral contraceptives.

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