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Acute ischemic stroke: low dose intravenous thrombolysis or can effectively reduce the risk of bleeding


2016 European stroke organization meeting, a study in Australia shows that reducing the dose of intravenous thalidomide (rtPA) can effectively reduce the probability of severe bleeding and improve patient survival. The study has been published in the New England Journal of Medicine. (Medscape website)

RtPA intravenous thrombolysis can be used to treat patients with acute ischemic stroke, but the drug by blocking the blood vessels in patients with obstruction of the blood vessels at the same time, may cause about 5% of severe intracranial hemorrhage, leading to death.

The study focused on improving the management of hypertension and thrombolytic therapy (ENCHANTED), into the world's 100 hospitals, more than 3,000 patients, including more than 1,400 cases of Chinese patients. Small doses of rtPA (0.6mg / kg) can reduce 2/3 of intracranial hemorrhage. 8.5% of patients died after 90 d of low doses of rtPA, and 10.3% in the standard dose group. (Qiu Jia)

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